DESIGN, DEVELOPMENT AND EVALUATION OF COLON TARGETED MATRIX TABLETS OF IBUPROFEN
In the present work, colon targeted matrix tablet of Ibuprofen was formulated to colon targeted release of Ibuprofen above its site of absorption. Ibuprofen possesses analgesic and antipyretic activities. Its mode of action, like that of other NSAIDs, is not completely understood, but may be related to prostaglandin synthetage inhibition. In clinical studies in patients with rheumatoid arthritis and osteoarthritis, Ibuprofen have been shown to be comparable to aspirin in controlling pain and inflammation and to be associated with a statistically significant reduction in the milder gastrointestinal side Gastroscopic studies at varying doses show an increased tendency toward gastric irritation at higher doses. Ibuprofen is well absorbed throughout the gastrointestinal tract and is therefore suitable as a model drug in relation to study of colon-specific formulations. Tablets of ibuprofen were prepared by direct compression method by rotary tableting machine using 10 mm round, concave punch. Microcrystalline cellulose is used as diluent. Mixture of talc and magnesium state was used as lubricant. Guar gum and pectin were included in various proportions. Various effects of both Guar gum and Pectin on the drug release were noted. Results show that when Guar
gum was used alone in a concentration of 10 % in batch-A, the tablets disintegrate within one minute, i.e., these tablets will release 100 % of drug in stomach, this shows that Guar gum in such a low concentration is not able to provide a cohesive strength to tablets. There is significant interaction between Guar gum and Pectin. Effect of Guar gum is less than Pectin in retardation of drug release in first five hours of drug release. So there is a need to study a formulation having medium percentage of both Guar gum and Pectin.